脑与认知功能障碍研究室

脑与认知功能障碍研究室

 

脑与认知功能障碍研究室成立于20154月,采用多学科结合手段,从基因-神经环路-行为的角度,揭示认知功能相关神经环路在重大神经、精神疾病发生、发展中的变化规律,为深入理解神经、精神疾病认知功能障碍的发病机制,发现新的预防、诊断和治疗手段提供科学依据,提高人民的心理健康水平做出贡献。本团队现有8人,其中6人有博士学历,3位有海外留学和工作经历,1位实验员,1位实验室管理人员。在神经发育疾病、神经退行性疾病、脑血管病的发病机制、临床转化研究方面处于国内领先水平。

 

  

研究方向:


1. 情感和记忆相关神经精神疾病的神经环路机制

2. 脑认知功能障碍相关疾病新药筛选及干细胞治疗

3. 脑认知功能障碍相关疾病转化医学研究

4. 心脑血管疾病发病机制及药物治疗靶点研究

5. 糖尿病脑认知、心血管功能障碍机制与药物靶点研究

 

  

承担课题:


1.      国家自然科学基金面上项目(No.81571095),ICAM5RNA结合蛋白FMRP的动态关联机制及其对脆性X综合征树突棘成熟的影响,2016/1-2019/1269万,主持人:曾燕。

2. 国家自然科学基金面上项目(NO.31271199),TrkB激动剂7,8-dihydroxyflavone对脆性X综合征突触可塑和学习记忆的影响及机制,2013/1-2016/1287万,主持人:曾燕。

3. 湖北省卫生与计划生育委员会(NO.WJ2015MB050),端脑素(Telencephalin)RNA结合蛋白FMRP的动态关联对脆性X综合征神经元树突棘成熟的影响与机制,2015/03-2017/0310万,主持人:曾燕。

4. 武汉市科技攻关计划(NO2013060602010278),7,8-dihydroxyflavone对阿尔茨海默病学习记忆的改善作用研究,30,主持人:曾燕。

5. 国家自然科学基金青年基金(NO81102437),SIRT2调节心肌细胞微管稳定性与糖尿病心肌病关系研究,2012/1/1-2014/12/3121万,主持人:袁琼。

 

  

科研成果:


1. Gao Lei, Tian Mi, Zhao Hong-Yun, Xu Qian-Qian, Huang Yu-Ming, Si Qun-Cao, Tian Qing, Wu Qing-Ming, Hu Xia-Min, Sun Li-Bo, McClintock SM, Zeng Yan*. TrkB activation by 7, 8-dihydroxy?avone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.  Journal of Biochemistry, Accepted.

2. Tian Mi, Zeng Yan*, Hu Yilan, Yuan Xiuxue, Liu Shumin, Li Jie, Lu Pan, Sun Yao, Gao Lei, Fu Daan, Li Yi, McClintock SM. TrkB agonist 7, 8-dihydroxyflavone changes synapse expression of AMPA subunits and ameliorates behavioral and spine abnormalities in a mouse model of fragile X syndrome. Neuropharmacology. 2015; 89: 43-53.

3. Zeng Yan*, Wang Xiaonan, Wang Qiang, Liu Shumin, Hu Xiamin, McClintock SM. Small molecules activating TrkB receptor for treating a variety of CNS disorders. CNS Neurol Disord Drug Targets. 2013, 12(7):1066-77.

4. Zeng Yan*, Chang Wei, Shu Chang, Ma Lina, Huang Yuanyuan, Wang  Ruoshi, Zhang Junpeng, Zhu Changcai, McClintock SM. Decreased cognitive function in extended family members from the single late-onset-Alzheimer's-disease pedigree. J Int Neuropsychol Soc. 2013, 19(7):809-19. 

5. Zeng Yan*, Liu Yakun, Wu Mianyun, Liu Jun, Hu Qi. Activation of TrkB by 7, 8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. J Alzheimers Dis. 2012, 31(4):765-78.

6.Zeng Yan*, Lv Feng, Li Long, Yu Hui, Dong Min, Fu Qinghai. 7, 8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J Neurochem. 2012, 122(4):800-11.

7. Zeng Yan, Tan Miao, Kohyama J, Sneddon M, Watson JB, Sun YE, Xie CW. Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci. 2011, 31(49):17800-10.

8. Zeng Y, Zhao D, Xie CW. Neurotrophins enhance CaMKII activity and rescue   amyloid-β- induced deficits in hippocampal synaptic plasticity. J Alzheimers Dis. 2010, 21(3): 823-31.

9. Zeng Y, Lv X, Zeng S,Tian SL, Shi J. Activity-dependent neuronal control of gap- junctional communication in fibroblasts. Brain Research. 2009, (1280):13-22.

10. Zeng Y, Lv XH, Zeng SQ, Shi J. Sustained depolarization-induced propagation of  [Ca2+]I oscillation in cultured DRG neurons: the involvement of extracelluar ATP and P2Y receptor activation. Brain Research. 2008, (1239):12-23.

11. Jiang H, Tian S, Zeng Y, Li L, Shi J. Nerve growth factor inhibits Gd(3+)-sensitive calcium influx and reduces chemical anoxix neuronal death. J Huazhong Univ Sci Technolog Med Sci. 2008, 28(4): 379-82.

12. Jiang H, Tian SL, Zeng Y, Li L, Shi J. TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen-glucose deprivation. Brain Research Bull. 2008, 76(1-2):124-30.

13. Tian SL, Jiang H, Zeng Y, Shi J. NGF-induced reduction of an outward-rectifying  TRPM7-like current in rat CA1 hippocampal neurons. Neuroscience Letter. 2007, 419(2):93-98.

14. Zeng Y, Liang XC, Dai JP, Wang Y, Yang ZL, Li M, Huang GY, Shi J.   Electroacupuncture modulates cortical activities evoked by noxious somatosensory stimulations in human. Brain Research. 2006, 1097(1): 90-100.

15. Yuan QHu CPGong ZCBai YPLiu SYLi YJJiang JL. Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: Role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginineBiochem Biophys Res Commun, 2015,458(4):869-76.

16. Yuan Q, Bai YP, Shi RZ, Liu SY, Chen XM, Chen L, Li YJ, Hu CP. Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner. Cell Biol Int. 2014,38(9):1013-22.

17. Yuan Q, Zhou QY, Liu D, Yu L, Zhan L, Li XJ, Peng HY, Zhang XL, Yuan XC. Advanced glycation end-products impair Na?/K?-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway. Clinical and Experimental Pharmacology and Physiology, 2014,41(2):127-33.

16.  Yuan Q, Peng J, Liu SYWang CJ, Xiang DX, Xiong  XM, Hu CP, Li YJ . The inhibitory effect of resveratrol derivative BTM-0512 on high glucose–induced cell senescence involves DDAH/ADMA pathway. Clinical and Experimental Pharmacology and Physiology, 2010, 37: 630-635.

17.  Yuan Q, Chen L, Xiang DX, Li YJ, Hu CP. Effect of resveratrol derivative   BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1. Can J Physiol Pharmacol. 2011,89(10):713-22.

18.  Hu W, Yuan Q, Liu XH, Zhu HC, Lv SQ, Wang XH. Cyclophilin D-mediated apoptosis attributes to sorafenib-induced cytotoxicity in clear cell -renal cell carcinoma. Eur J Pharmacol. 2015,749:142-50.

19.  Bai YP, Hu CP, Yuan Q, Peng J, Shi RZ, Yang TL, Cao ZH, Li YJ, Cheng G, Zhang GG. Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis. Free Radic Biol Med. 2011, 51(8):1492-500. (SCI: 5.423)

20.  Shi RZ, Hu CP, Yuan Q, Yang TL, Peng Jun, Li YJ, Bai YP, Cao ZH, Cheng GJ,Zhang GG. Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation. Cardiovascular Research. 2011, 91(1):27–36.

21.  Chen XM, Xia J, Zhou T, Yuan Q, Zhang WF, Hu CP, Li YJ, Jiang JL. Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats. Int Immunopharmacol. 2013 16(2):322-31.

24.Chen BLiu YL, Jin XW, Lu WL, Liu JP, Xia ZJ, Yuan Q, Zhao Xia, Xu NZ, Liang SF. MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells, BMC Cancer, 2014, 14.

 

 

 

承担大学生创新课题

1.      国家级大学生创新课题

 7,8-dihydroxyflavone对阿尔茨海默病小鼠模型Tg2576学习记忆的改善作用研究》主持人:李龙,指导老师:曾燕。

SIRT1DPP-4/GLP-1调节糖尿病内皮祖细胞衰老关系的研究》主持人:赵攀,指导老师:袁琼。

2.      省级大学生创新课题

《神经特异性细胞间粘附分子ICAM5AMPA受体相互作用对脆性X综合症神经元树突棘发育的影响》主持人:李翔宇,指导老师:程桂荣。

SIRT3调节心肌细胞能量代谢与糖尿病心肌病关系的研究》主持人:徐洁,指导老师:周乾毅。

3.      校级创新课题

7, 8-Dihydroxyflavone, 新发现的TrkB受体小分子激动剂对老年SD 大鼠空间学习记忆的影响》主持人:马丽,指导老师:曾燕。

SIRT2诱导脑组织损伤与糖尿病脑病的关系》主持人:王强,指导老师:袁琼

SIRT1介导心肌细胞衰老与AGEs诱导糖尿病心肌病关系》主持人:俞仑,指导老师:袁琼

 

  

实验室大学生获奖


1. 湖北省第十届挑战杯7, 8-dihydroxyflavone对阿尔茨海默病小鼠模型Tg2576学习记忆的改善作用研究湖北省一等奖,授奖单位:团省委、教育厅,指导老师,曾燕。

 

 


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